Established in 1994 as a wholly owned subsidiary of Biocon Limited, Syngene International Private Limited (Syngene) is an internationally reputed chemical synthesis-driven Custom Research Company with multi-disciplinary skills in Synthetic Chemistry and Molecular Biology. Leveraging the convergence of information technology and biotechnology, Syngene conducts high value R&D in early stage drug discovery and development for a diverse global clientele.
Syngene provides customised R&D services in early stage drug discovery and development to pharmaceutical and biotechnology companies worldwide. With state-of-the-art facilities, dedicated connectivity and highly qualified researchers, Syngene offers its customers a powerful value advantage in the field of outsourced research and development. Our teams of highly skilled scientists offer clients quality services with particular attention to confidentiality, time-lines and cost-effectiveness.
Syngene's small molecule team designs the synthesis of complex organic molecules using reported or novel reaction schemes. We have the expertise to handle alkyl lithiums, air and moisture sensitive reagents, reactions under inert conditions, metal mediated reactions, etc. Access to various databases like Scifinder and Beilstein Crossfire help us to plan the reaction schemes, while the Available Chemicals Directory (ACD) enables us to identify the source of the starting materials. We use state-of-the-art analytical facilities to identify prepared compounds and elucidate the structure of synthesised molecules in order to ascertain their purity.
Syngene's Combichem team has particular competence in providing custom-synthesised building blocks for the construction of combinatorial libraries. We have acquired technical capabilities in scaling up complex chemical and biochemical processes. Our cGMP accredited pilot plant (glass-lined and stainless steel chemical reactors: 20l -1500l) is fully equipped to develop intermediates and final products.
Syngene's custom synthesis unit supplies novel boronic acids and customised molecules at a kilogram scale to several highly reputed research units in the USA and Europe. We also prepare small peptides at multi-gram scale for numerous customers. The most recent addition to our expertise is the preparation of chemical libraries using our parallel synthesis and purification systems. Novel process development for API's, intermediate synthesis, synthesis of standard impurities and reference compounds are also routinely carried out at this unit.
Synthesis of organic molecules involves diverse chemistry. Some of the reactions carried out by our custom synthesis unit at gram to kilogram scale include:
In addition, Syngene conducts reactions under low temperature, inert conditions and carbonylation using triphosgene. Over the years, we have acquired experience in multi-step synthesis and the preparation of protected amino acids.