In part 1 of this article you were introduced to the business unit Grinding & Dispersing of the family-owned company NETZSCH. Besides the machine design there are other essential conditions for the successful comminution or dispersion of solids. These are the right formulation of the product suspension as well as the selection of the best grinding media and the optimal operating parameters of the mill.
The comminution or desagglomeration of active pharmaceutical ingredients (API) is called micronization. Nanonization is a term for reducing particle size to the nanometer range and brings about several advantages. It further increases the surface area of API’s which could result in enhanced solubility and drug bioavailability. Reducing the particle size of an API possessing poor solubility characteristics can lead to higher specific surface area, thereby increasing bioavailability and dissolution rate. Due to the increased bioavailability a lower amount of API is required which in turn leads to a more cost-efficient product with less risks and side effects for the patient.