Laboratoria Smeets - Filling line, Sachet line, Laboratory, Twin Screw Granulator (Thermo Fisher Pharma TSG 24)

Laboratoria Smeets is a Belgian company with more then 30 years of experience in contract manufacturing and contract packing activities for (para) pharmaceutical products. The company is located near Antwerp All activities are performed under cGMP conditions. The core values of Laboratoria Smeets are Excellence – Confidence - Flexibility -Transparency.

Laboratoria Smeets offers –

Contract manufacturing activities:

Mixing activities of powders and liquids.

Contract packing activities:

Sachet packing of powders and liquids.

Proprietary developments:

Patented granulation technology for improving water solubility of API’s, Innovative treatments for Constipation, Rheumatoid Arthritis, Osteoarthritis available for distribution, Stability studies.

Power Blending:

The blending facility is fully equipped to handle powders in a controlled way. From sampling to blending, everything is performed under controlled atmosphere. Temperature, humidity and relative pressure are regulated. Dust aspiration units are available everywhere. 

Unique sachet know-how:

The sachet material is usually a paper/ aluminum/ polyethylene extrusion laminate. In some cases Surlyn is used for dealing with sealing issues.

Polyester/ aluminum/ polyethylene is also a popular sachet material. An interesting possibility is the usage of peelable material in combination with the polyester laminate. Other barrier materials such as EVA, PVA, Siox, or Melamine are also an option. 

The printing techniques:

These are the traditionally known techniques. Sachet material is printed very much the same way labels are printed. This gives a lot of flexibility. In most cases they use flexo printing.

For higher quality printing Offset printing is used. Interestingly, sachet material is easy to be printed with the latest generation of digital presses. This can be done through toner or liquid based technology. The results for the digitally printed sachets are outstanding.

New technology for continuous production of water soluble granules containing APIs via Twin Screw Granulation

Improving water solubility and bioavailability of APIs.

Labo Smeets (Wilrijk, Belgium) has developed in collaboration with Ghent University a technique to produce water-soluble granules containing poorly water soluble drugs of Class II (poorly soluble, highly permeable) or Class IV (poorly soluble, poorly permeable) of the Bio Classification System (BCS).

The innovative and patented technology can be used for the production of water-soluble granules of human or veterinary medicines. First applications are the production of granules of antibiotics administered via drinking water to treat large groups of animals (poultry, pigs,) as opposed to administering these antibiotics via the food. The produced granules can also be filled in capsules or can be used as intermediates for the production of tablets.