NOTOX B.V.

Notox, located in The Netherlands, USA, Japan and Switzerland, is a member of the WIL Research Holding Company, Inc. The services offered by the company include:

Regulatory toxicology studies supporting IND / NDA

We offer a complete set of toxicology studies for supporting your IND / NDA. Services range from in vitro genetic testing (Ames, Chromosome Aberration, Micronucleus) to full regulatory in vivo studies, acute to chronic toxicity, carcinogenicity, reproduction and developmental studies, safety pharmacology (core battery), immuno-toxicology (core battery) and environmental risk assessment. Studies are conducted in a wide variety of rodent and non-rodent animal species using all common routes of administration. Full analytical support includes formulation analysis, bioanalyses, biomarkers and cytokine analyses.

Exploratory research and support

In addition to the regulatory required studies we offer over 20 years of experience in dedicated personalized services to profile your candidate drug better. Our scientists design tailor-made studies using in vitro techniques (e.g. CYP450 inhibition / induction with fresh or cryo-preserved human hepatocytes) to understand ADME and interactions. The application of sophisticated mass spectrometry or radiometry techniques with both in vitro and in vivo models enables elaborate drug / metabolite elucidation.

All studies are performed by over 250 specialists in accordance with the principles of Good Laboratory Practice (OECD/EPA/FDA/JMAFF) in a purposely built state-of-the-art 95,000ft2 facility located in The Netherlands with support offices in the USA, Japan and Switzerland.