EXPERIMENTAL TOXICOLOGY SERVICES (ETS) NEDERLAND BV - CUSTOM DESIGN OF NON-CLINICAL R&D PROGRAMMES, CONTRACT RESEARCH ORGANISATION SELECTION, STUDY MONITORING, INVESTIGATIONAL NEW DRUGS, TOXICOLOGY DATA ANALYSIS AND REPORTING

Experimental Toxicology Services (ETS) Nederland BV, based in Zutphen, The Netherlands, is an independent - privately owned - product development consultancy. ETS is managed by Henk Tennekes, a highly experienced Eurotox-certified toxicologist. ETS ensures that pivotal non-clinical programmes on the critical path are in safe hands.

Custom Design of Non-Clinical R&D Programmes
Experimental Toxicology Services (ETS) Nederland facilitates fast and high quality custom design of non-clinical R&D programmes. The custom design of non-clinical R&D programmes is conducted in close collaboration with R&D departments of pharmaceutical and biotech companies. ETS, with its custom design of non-clinical R&D programmes, aims to deliver safe and effective medicines quickly and efficiently. Custom design of non-clinical R&D programmes generates a portfolio of non-clinical development services, delivered through leading contract research organisations.

Contract Research Organisation Selection
Experimental Toxicology Services (ETS) Nederland provides a range of services for pharmaceutical industry including contract research organisation (CRO) selection. ETS, in its contract research organisation selection process, objectively selects CROs that best suit the needs of the sponsor, and provides the sponsor with an insight into real costs. ETS, in the contract research organisation selection process, mediates between sponsor and CRO. The contract research organisation selection services also include coordination and follow-up of studies, study design and protocol review of in vivo and in vitro studies (ADME, toxicology, and secondary pharmacology), and pharmacokinetic (PK) and toxicology data analysis and reporting. PK and toxicology data analysis within competitive timelines is also a part of contract research organisation selection. The timelines are discussed with the sponsor’s project team. The contract research organisation selection services also include monitoring of studies in CROs. Leading pharmaceutical companies have entrusted the contract research organisation selection process and the implementation of non-clinical research programmes to ETS.

Study Monitoring
Henk Tennekes directed numerous general toxicity and carcinogenicity studies, ensuring high quality study monitoring with pharmaceuticals. He has successfully managed the general toxicology department of a major European contract research laboratory from 1986-1992. Since 1992, he has provided consultancy and study monitoring services to leading companies in the chemical industry, with an acknowledged record of achievement. Henk Tennekes was the Secretary of the Toxicology Section of the Swiss Society of Pharmacology and Toxicology from 1992-1998 and in 1995 chaired the Task Force of the Swiss Society of Pharmacology and Toxicology on Guidelines for Training and Registration of Toxicologists in Switzerland. He was a Member of the Board of Directors of the Swiss Register of Toxicologists from 1996-2000.

Investigational New Drugs
Experimental Toxicology Services (ETS) Nederland provides a wide range of services for pharmaceutical industry including development of investigational new drugs. Study monitoring with investigational new drugs by ETS ensures that pivotal non-clinical studies on the critical path are in safe hands. The primary goal of non-clinical studies with investigational new drugs is to support all stages of clinical development. ETS ensures that the investigational new drugs are provided with an effective and strong non-clinical foundation. . The research facilities used by ETS for investigational new drugs are world class. As a matter of course, the company follows all the regulatory standards for investigational new drugs. Besides services for investigational new drugs, ETS also facilitates New Drug Applications (NDA). ETS has collaborated with R&D departments of various pharmaceutical and biotech companies on investigational new drugs.

Toxicology Data Analysis and Reporting
Toxicology data analysis and reporting is also a major part of the services of Experimental Toxicology Services (ETS) Nederland. The company maintains a very high standard in toxicology data analysis and reporting. ETS provides invaluable expertise for toxicology data analysis and reporting. Henk Tennekes himself, the CEO of the company, is an expert in risk assessment and oversees toxicology data analysis and reporting... He has authored and co-authored a considerable number of important papers in leading scientific journals, including ones on toxicology data analysis and reporting: Some of his most recent publications include: 

H. Tennekes, C. Gembardt, M. Dammann and B. van Ravenzwaay (2004).The stability of historical control data for common neoplasms in laboratory rats: adrenal gland (medulla), mammary gland, liver, endocrine pancreas and pituitary gland. Regulatory Toxicology and Pharmacology 40, 18-27.

H. Tennekes, W. Kaufmann, M. Dammann and B. van Ravenzwaay (2004)
The stability of historical control data for common neoplasms in laboratory rats and the implications for carcinogenic risk assessment. Regulatory Toxicology and Pharmacology 40, 293-304

K. Deckardt , I. Weber, U. Kaspers, J. Hellwig, H. Tennekes, and B. van Ravenzwaay (2007).The effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats. Food Chem Toxicol. 45(9),1709-18