Presspart - Meter Dosed Inhalers (MDIs), Actuators, Plasma Technology, Plastic division and Deep drawing
With more than 40 years' experience and a worldwide reputation for competence, quality and innovation, Presspart specialises in high precision, deep drawn components for the Pharmaceutical industry.
Presspart specialises in bespoke, concept-to-completion, metal and plastic drug delivery components and devices that help pharmaceutical companies deliver drugs of the present and future. Presspart constantly studies, refines and optimises its processes to ensure optimum quality and performance for its customers.
Meter Dosed Inhalers
Presspart is the world’s leading manufacturer of canisters for meter dosed inhalers (MDI) – testament to our knowledge and experience of the market. Their reputation for competence, quality and innovation puts Presspart at the forefront of the game.
Presspart’s expertise ensures each canister is designed and manufactured for optimum compatibility with the Meter Dosed Inhaler valve, actuator and formulation. The complete range of canisters is suitable for use with both hydrofluoroalkanes (HFA) and chlorofluorocarbon (CFC) propellants, and is available in a number of sizes and substrates. A range of coatings are also available.
Presspart has over 35 years’ experience in supplying metal meter dosed inhaler (MDI) canisters, valve components, plastic actuators and new drug delivery devices. The company supplies most of the major pharmaceutical companies and has a significant presence with the newer Asian pharmaceutical companies.
One of the most significant advancements is pioneering new can solutions for the Meter Dosed Inhaler industry as it moves from CFC to HFA propellants. Presspart has the largest range of Meter Dosed Inhaler solutions for HFA formulations and are the largest supplier of internally coated MDI cans in the world.
Plasma Technology
Presspart’s new sub-micron plasma process coats and treats the internal surfaces of plasma MDI canisters. Plasma Coating and treatments offer solutions for deposition of the drug suspension on the canister wall. Deposition of the active content of a drug formulation on can surfaces is a problem with some MDI products. This ultimately leads to a reduction in the drug content in the formulation, resulting in the patient receiving less than the prescribed dose. Presspart’s Plasma Technology can improve the surface energy performance of a Meter Dosed Inhaler and reduce deposition. It can also improve the stability of some formulations where interactions with the aluminium substrate can lead to product degradation and reduced shelf life.
Plastic Division
Presspart also specialises in the production of injection moulded plastic components, drug delivery devices and value added sub-assemblies for the pharmaceutical and healthcare sector.
Presspart has expanded its capabilities and built expertise solely within the pharmaceutical and healthcare industry sectors, reassuring customers of our market knowledge and understanding of current market requirements, as well as offering the latest in technologies.
All manufacturing and assembly takes place under clean room conditions and the moulding machines range from 50 to 350 tonnes. Presspart has experience in working with a wide range of plastic resins including polypropylene, polyethylene HD and LD, ABS, TPE (Santoprene), polystyrene, POM, PA 66, EVA and K-resin
Deep Drawing
Presspart is one of the world’s leading manufacturers of deep-drawn precision components, serving the pharmaceutical industry.
Products can be deep-drawn from a range of metals including aluminium, stainless steel, carbon steel, brass, nickel, inconel and galfan.
Presspart’s ability to manufacture parts that have traditionally been manufactured by other processes, such as turning, offers many benefits:
- » Less material is used in the deep drawing process thereby reducing material waste and ultimately cost
- » The quality of a deep-drawn product is often superior compared to other manufacturing processes
- » Complex designs often not possible with other processes can be achieved with deep-drawing
- » Batch-to-batch repeatability ensures consistency in the production of components
PROFILE TOOLS
Meter Dosed Inhalers
Plasma Technology
The most commonly used methods to manufacture metal canisters for MDIs are deepdrawing or impact extrusion; both techniques are well established for manufacturing across many industrial sectors. During impact extrusion, a hollow shell is formed from cold metal billets using a single stage, high impact punch, whereas deep-drawing forms a properly contoured can over multiple stages from a rolled metal sheet. The deep-drawing method has several advantages over impact extrusion, particularly for meeting the stringent requirements of the pharmaceutical industry.
The optimal size of the canister depends mostly on dosing requirements and, therefore, the volume of drug formulation. The volume of each dose and the number of doses per canister will determine the canister volume. However, the larger the canister, the larger the actuator will have to be, and this may affect portability and ergonomics. The canister's dimensions must fit closely with the other MDI components, especially the valve, to prevent leakage.
The molecular properties of an HFA-MDI's active pharmaceutical ingredient can cause it to interact with the canister. When drug formulations are in suspension, the interaction can result in drug deposition on the canister wall or exposed surfaces of the valve components, and interactions with solutions more commonly cause degradation, resulting in increased impurity levels. In both cases the interaction leads to a reduction in the drug content in the formulation,resulting in the patient receiving less than the prescribed dose.
"THE RESULT IS A COATING TECHNOLOGY WITHOUT THE EXTRACTABLE ISSUES POTENTIALLY ENCOUNTERED WITH SOME POLYMER SYSTEMS."