Company : GlycoMar Limited

Category : Biotechnology

Key Products : Drug discovery, Nutraceutical markets

GlycoMar is an innovative biotechnology company simultaneously developing marine natural products for the pharmaceutical, cosmeceutical, and nutraceutical markets. GlycoMar distinguishes itself from other biotechnology companies by focusing on marine glycobiology giving it unique access to a class of proprietary novel molecules with invaluable biological profiles. GlycoMar also offers a range of complementary contract research services, giving customers access to it range of bespoke anti-inflammatory screening assays and glycobiology analytical tools.

Drug discovery

GlycoMar is uniquely focused on the development of novel therapies based on saccharide molecules from marine organisms. These molecules offer a unique therapeutic approach with an excellent safety profile. The company has developed a unique library of polysaccharides and glycosaminoglycans. The molecules have been the subject of compositional analysis and structural characterisation. Anti-inflammatory screening has shown a high hit rate of valuable activity, which is being developed for treatment of psoriasis, inflammatory bowel disease, and respiratory inflammatory disease in collaboration with a pharmaceutical partner.

GlycoMar is seeking partners for its psoriasis and inflammatory bowel disease programme. GlycoMar is also interested to talk to commercial partners interested in testing out molecules in other disease indications.

Nutraceutical discovery

GlycoMar has developed processes for the production of novel active saccharide from unicellular marine microalgae. These products are sustainably produced from naturally occurring marine microalgae. They have the following properties which can support a wide range of claims:

Properties of nutraceutical & cosmeceutical saccharide

  • Activity
  • Anti-inflammatory activity relevant to joint-care, skin-care and eye-care
  • Non-toxic, non-irritant
  • Non-animal polysaccharides and oligosaccharides
  • Marine natural product
  • Chemical free extraction – truly natural
  • Non-GM
  • Sustainably produced with no environmental impact
  • High quality product

GlycoMar’s nutraceutical and cosmeceutical ingredients compare very favourably with existing saccharide products from botanical or animal sources. 

Drug discovery screening

GlycoMar specialist screening facility has been established to provide flexible in vitro screening services to a wide range of organisations involved in therapeutic discovery. GlycoMar offers a suite of cost effective primary screens, using cells from healthy human donor volunteers and cell lines:


Marker

Cell type

Inflammatory Cytokine profiling

Human whole blood, PBMCs, or Neutrophils, keratinocytes, or endothelial cells

Elastase release

Human Neutrophils

Chemotaxis

Human Neutrophils

Transendothelial migration

Human Neutrophils, human umbilical vein endothelial cells (HUVECs)

Oxidative burst

Human Neutrophils and lymphocytes

Activated Partial Thromboplastin Time (APTT)

Fresh human plasma sheep plasma

Cytotoxicity

BHK & HeLa cells

Glycobiology analytical services

GlycoMar specialist analytical laboratory has been established to provide compositional analysis of saccharide molecules, including glycosaminoglycans. We can also offer full structural analysis of GAGs by NMR.

Analytical services


Analysis

Description

HPLC-SEC

Molecular weight and purity determination by HPLC with PDA and/or RI detection

Monosaccharide analysis

Monosaccharide composition analysis of purified materials by GC-MS

Disaccharide analysis

Disaccharide composition analysis of glycosaminoglycans by HPLC-PDA

Linkage analysis

Polysaccharide linkage analysis by methylation analysis

Fourier Transform Infra Red spectroscopy

FTIR analysis of purified materials by GC-MS

Nuclear Magnetic Resonance (NMR)

Structural determination of glycosaminoglycans

Contact Details

GlycoMar Limited
European Centre for Marine Biotechnology
Dunstaffnage Marine Laboratory
Dunbeg, Oban
Argyll
Scotland
PA37 1QA
Tel: +44 (0)1631 559 370
Fax: +44 (0)1631 559 010
Email: info@glycomar.com
Website: www.glycomar.com

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