EpiScreen™ Time Course T Cell Assay
EpiScreen™ is an accurate and sensitive way to assess the potential immunogenicity of proteins and antibodies ex vivo by measuring CD4+ T cell responses, the primary drivers of memory-based immunogenicity. The EpiScreen™ time course T cell assay is used extensively across the industry as a standard for preclinical immunogenicity testing.
The assay provides an accurate and sensitive way to assess the overall immunogenicity of protein therapeutics during early lead selection or during manufacturing. For each study a donor cohort is selected to best represent the distribution of HLA-allotypes in the human population.
By measuring CD4+ T cell responses ex vivo, the assay assesses the strength and kinetics of an individual’s T cell response to a protein therapeutic, thereby giving an indication of an immunogenic response against the protein.
The assay can facilitate lead selection based on the immunogenicity of whole proteins including mAbs and other human and non-human protein therapeutics. It can also assess the immunogenicity following antibody humanisation and protein deimmunisation.
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