Most pharmaceutical dosage forms applied directly to the skin for topical action are classified as semisolid, a group of products which include ointments, creams and gels. They are typically applied for immediate, localised relief. These products are typically hydrocarbon-based or oil-in-water emulsions incorporating additional ingredients such as emulsifiers, stabilisers, pH buffers, preservatives, absorption promoters and perfumes. USP Chapter <1724> details the performance testing required for semisolid drug products.
There are three different apparatuses for the in vitro determination of drug release from semisolid drug dosage forms:
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