Avivia BV.

Avivia Dissolution Testing Services

Avivia Dissolution Testing Services

The experience and knowledge-based pharmaceutical dissolution development platform within Avivia focuses primarily on supporting formulation development and problem solving.

For us, dissolution testing is never a routine test, but an essential tool in pharmaceutical formulation development to:

• evaluate the physico-chemical properties of drug candidates to select the most appropriate solid form for further development (pre-formulation)
• perform biorelevant in-vitro tests to mimic fed and fasted state conditions
• compare prototype formulations (preclinical selection)
• elucidate drug release mechanism (diffusion, erosion, etc.)
• as an indicator of stability (e.g., temperature, humidity)
• as an indicator of the robustness of the manufacturing and
• assure safe release and reproducibility of the products to the market.

Dissolution testing should be a discriminatory method that is sensitive to variables affecting release rate and ideally has a predictive value for bio-performance.

It takes a lot of skills, knowledge and experience to design dissolution testing methods that contribute to the development of safe, robust and successful pharmaceutical dosage forms.