Celares

Bioconjugation

Bioconjugation is the covalent chemical connection between a biomolecule, i.e. a protein, a peptide or an oligonucleotide, and another, typically a synthetic, molecule. Well-known examples of bioconjugates are conjugate vaccines (e.g., Prevnar 13®), PEGylated biologics (e.g., Neulasta®) or antibody drug conjugates (ADCs, e.g., Kadcyla®).

Modification of biologics with polymers/PEGs or small molecule drugs requires extensive experience in chemistry and a sound understanding of the particular biologic. celares GmbH has a proved track record in the development of bioconjugates. We are familiar with all varieties of bioconjugation methods, including PEGylation and glycoconjugation, as well as with small molecule or peptide coupling. Our services are offered at any stage of a bioconjugate development ranging from first feasibility studies through process and analytical method development, to the manufacturing of investigational medicinal products for first-in-man studies.

You can count on our decades of experience in bioconjugation. Find more details about our capabilities and services