In-Vitro Toxicology
CPT℠ offers an array of non-animal (in-vitro) methodologies.
Whether you require safety data before proceeding with clinical testing or you are looking for stand-alone results, with our decades of in-vitro experience, we can provide rapid and reliable results.
In-vitro toxicology studies the effects of toxic chemical substances on cultured cells or micro-tissues. It is used primarily to identify potentially hazardous chemicals in the early stages of the development of new pharmaceuticals or cosmetics.
Our current In-Vitro Toxicology offerings are detailed below:
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Eye Irritation Equivalency Assays
The table below attempts to correlate product types with irritation potential and the corresponding test methodologies. One or more of these methods is sure to be appropriate for your test article.
The EpiOcular EIT is an in-vitro assessment assay that has the ability to differentiate articles that are ocular irritants from articles that are not ocular irritants. The EIT is accepted as OECD TG 492.
The Bovine Corneal Opacity and Permeability test method (BCOP) is an in-vitro test method that can be used to classify substances as ‘ocular corrosives and severe irritants. The BCOP is accepted as OECD TG 437.
The EpiOcular MTT ET-50 (Neat) method is a risk assessment assay based on the effective time at which a material (applied neat) causes a 50% reduction in tissue viability (ET-50). Based on the ET-50, the test article is categorized into one of 4 classifications ranging from non-irritating to severe/extreme which correspond to groupings of Rabbit Draize Eye Scores (MMAS).
The EpiOcular MTT ET-50 (Dilution) method is similar to the MTT ET-50 Neat method. This assay is based on the effective time at which a material (diluted to 20% in water) causes a 50% reduction in tissue viability (ET-50). Based on the ET-50, the test article is categorized into one of 4 classifications ranging from non-irritating to severe/extreme which correspond to groupings of Rabbit Draize Eye Scores (MMAS). This method is recommended for surfactant based solutions and is applicable to water-soluble materials with a specific gravity of > 0.95.
The EpiOcular Sub Draize Ultra-Mildness Test. This assay is routinely utilized for mild materials for which the Draize test is insensitive. This highly reproducible assay allows for quantifiable discrimination among mild, milder and mildest product formulations.
