Oral drug delivery is the preferred route of administration for the majority of medicines. Large numbers of molecules in the discovery and development pipelines of biotech companies demonstrate properties which have the potential to limit drug absorption from the gastro-intestinal tract and their subsequent systemic availability. At SEDA, we have experience of working in a wide range of projects with lead molecules demonstrating low aqueous solubility, low gastrointestinal permeability and a propensity for other exposure limiting factors such as pre-systemic metabolism or short half-life. In this regard, we have worked extensively in our laboratories to develop enabling formulations suitable for oral drug delivery in preclinical and clinical studies which address these issues and include:
Solubilised formulations containing complexing agents and lipidic surfactants
Amorphous solid dispersions
Salts and rapidly dissolving solid forms
Lipidic formulations
Micronised and sub-micron particulates
Sincerely Pharmaceutical Tech
Regards,
Client Success Team (CRM),
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Sincerely Packaging Labelling