HUTCHMED has entered into an exclusive development and licensing agreement with GSK for HMPL-A830, an investigational antibody-targeted therapy conjugate (ATTC) designed to target KRAS and EGFR in solid tumours.

EGFR is an established driver of tumour growth in several solid cancers, including colorectal, pancreatic and non-small-cell lung cancers. It also plays an important role in resistance to KRAS-targeted treatments, particularly in colorectal cancer. Targeting both EGFR and KRAS is therefore intended to provide broader and more durable pathway inhibition.

Under the agreement, GSK will receive worldwide development and commercialisation rights for HMPL-A830 outside Mainland China, Hong Kong, Macau and Taiwan. HUTCHMED will receive an upfront payment of US$110 million, along with potential development, regulatory and commercial milestone payments of up to US$1.295 billion and royalties on net sales.

HMPL-A830 combines a selective KRAS small-molecule inhibitor with an antibody that targets the epidermal growth factor receptor (EGFR). The approach is designed to deliver the KRAS inhibitor directly to EGFR-expressing tumour cells while also blocking EGFR and KRAS signalling.

The initial clinical development programme will focus on colorectal, pancreatic and lung cancers, which have high rates of KRAS alterations. KRAS mutations are particularly common in colorectal cancer, lung adenocarcinoma and pancreatic ductal adenocarcinoma.

Despite recent advances in KRAS-targeted treatments, many patients, particularly those with KRAS mutations other than G12C, continue to have limited treatment options. Resistance to existing therapies and toxicities associated with broader KRAS and RAS inhibition also remain challenges.

HUTCHMED will lead the global Phase I development programme for HMPL-A830, which is expected to begin in the second half of 2026. GSK will take responsibility for subsequent clinical development and commercialisation activities outside Mainland China, Hong Kong, Macau and Taiwan.

The agreement marks HUTCHMED's first licensing deal with a global partner for an asset from its ATTC platform and expands GSK's oncology pipeline with a novel dual-targeting approach.

 

Source: hutch-med.com

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