High pressure homogenisation is an efficient and easy to use technique for cell disruption. The principle is to pump the sample through a valve with a small aperture. The sample goes from very high pressure on the pump side of the valve to atmospheric pressure on the outlet side of the valve. This extreme change of pressure produces very high shear forces on the sample as it exits the valve. The effect on cells is to disrupt their membranes.
The Emulsiflex B15 uses a dynamic homogenising valve. The benefit of a dynamic valve is that the samples are processed at a constant homogenising pressure. Most cells are ruptured in a single pass thereby avoiding over processing and protein damage.
The homogenising pressure is adjustable between 500 and 45,000psi. It has a capacity of 15mL and it can process a sample as small as 3mL.The EmulsiFlex-B15 has no “O”-rings or gaskets in the product path. It is suitable for clean room and GMP manufacturing. The wetted parts are autoclavable and it is steam-in- place (SIP) sterilisable.
The EmulsiFlex-B15 has no “O”-rings or gaskets in the product path. It is suitable for clean room and GMP manufacturing. The wetted parts are autoclavable and it is steam-in- place (SIP) sterilisable.
This cell disruptor has an air driven pump which means that no electrical power is needed. It requires a supply of compressed or bottled air. For most emulsions, liposomes and E. coli rupture, an air pressure of 100psi is sufficient.
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