Thermogravimetric Analysis
What is Thermogravimetric Analysis?
The Thermogravimetric Analysis (TGA) is a remarkable technique used to characterize materials used in various pharmaceutical, food, environmental, and petrochemical applications. TGA measures the composition, purity, decomposition reactions, decomposition temperature and absorbed moisture content of your products.
How TGA Method Works
TGA-55 Equipment Used-for-Thermogravimetric-Analysis-TGA
TGA analysis provides the understanding of change in mass of a material in terms of both time and temperature. In this method the sample is heated from ambient to 1000 degree in nitrogen or air, then the resultant weight loss is calculated which occurs due to semi volatile compounds, polymer degradation, ash content, carbon black and moisture. The loss of surface absorbed solvent can be distinguished from solvent in the crystal lattice and from degradation losses. The measurements are carried out in atmospheres having controlled humidity and oxygen concentration to reveal interactions with the drug substance, between drug substances, and between active substances and excipients or packaging materials.
What do we get from TGA?
- It is beneficial in routine analysis of content determination to get accurate understanding of sample composition.
- It helps in understanding the reactivity corrosivity of sample materials when exposed to specific environments.
- TGA analyzes the changes in size, shape and overall mass when exposed to varying temperatures.
- It gives accurate details of the mass change of the materials under test.
- It provides necessary data for a wide range of materials characterization objectives.
- Determines the stability of pharmaceutical drugs.
- Allows quantitative composition analysis.
- It determines the purity of a mineral, inorganic compound, or organic material.
- Helps in determining the water/carbon content or other residual solvents in a material.
- Allows analysis of reactions with air, oxygen, or other reactive gas.
Thermogravimetric Analysis Applications
Thermal Stability
TGA is used to evaluate the thermal stability of a material in a desired temperature range. A thermally stable material will have no observed mass change. Negligible mass loss corresponds to little or no slope in the TGA trace. TGA also gives the upper use temperature of a material. The material begins to degrade beyond this temperature.
