Mixer – Granulator High Shear
Mixer – Granulator High Shear
INTRODUCTION
High shear wet granulation process is extensively used in pharmaceutical industry to transform fine heterogeneous powders into homogeneous blend of granules with bigger size and density to improve flow and compactability for tabletting operation.
Features
FUNDAMENTALS
The tulip shape design of the bowl produces a roping action from the impeller into the high speed radically mounted chopper. The high shear forces result in intensive mixing of the components in a very short time period.
Liquid aspersion over the powder bed causes solid – liquid interaction producing densification.
In simple way, granulation proceeds initially by a Nucleation mechanism, the solid particles agglomeration induced by liquid to produce the granule. With additional liquid and time process individual granules, stick to each other by Coalescence yielding larger and dense granules.
Coalescence is a complete random process but Nucleation can be accurately controlled by adjusting the four critical parameters of the granulation process:
CONCLUSIONS
– MIC Developer high shear granulator allows accurate control of critical parameters of the process. The result is a quality granule with a reproducibile process.
– MIC Developer and industrial MIC-P are designed and equipped to fulfill the scale up central premise:
GEOMETRIC, KINEMATIK AND DYNAMIC SIMILARITY to obtain similar granulates in different size granulators adopting the mixing speed through scaled curves, while the other important variables adjust linealy or stay unchangeable.
