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This medicine should be swallowed with liquids such as water and should not be chewed or crushed.
1. Adults
1) Gastroesophageal reflux disease (GERD)
- Treatment of erosive reflux esophagitis: Administer 40mg once a day for 4 weeks.
In patients whose esophagitis does not cure or the symptoms persist, take another 4 weeks.
- Long-term maintenance therapy to prevent recurrence of esophagitis patients: 20 mg once a day, once a day
- Symptomatic treatment of gastroesophageal reflux disease without esophagitis:
· 20 mg once a day, once a day. If symptoms are not controlled after 4 weeks, additional treatment is required.
· Once symptoms are relieved, subsequent symptoms are controlled by administering 20 mg once a day.
· For adults, 20 mg once a day can be administered as needed. For patients who are at high risk of developing gastric and duodenal ulcers due to NSAID administration, it is not recommended to administer them whenever necessary for continuous symptom control.
2) Combination therapy with antibiotics for eradication of Helicobacter pylori
20 mg of this drug in combination with 1 g of amoxicillin and 500 mg of clarithromycin is administered twice a day for 7 days.
3) Short-term therapy for upper gastrointestinal symptoms (pain, discomfort, burning sensation) related to administration of nonsteroidal anti-inflammatory drugs (COX-2 non-selective, selective)
- Once a day, 20mg once a day. If symptoms are not controlled after 4 weeks, additional treatment is required. Clinical trials longer than 4 weeks have not been conducted.
4) Patients who need continuous NSAID administration
- Treatment of gastric ulcer related to NSAID administration: 20mg once a day, once a day. The duration of treatment is 4 to 8 weeks.
- Prevention of gastric and duodenal ulcers related to NSAID administration: 20mg once a day, once a day
5) The recommended initial dose for treatment of Zollinger-Ellison syndrome
is 40mg twice a day. Thereafter, the dose should be adjusted on a patient-by-patient basis, and treatment should be continued for as long as clinical symptoms exist. According to clinical data, most patients can be adjusted at a dose of 80 to 160 mg per day. Doses of 80 mg or more per day should be divided into two doses per day.
6) Maintenance therapy after induction of prevention of rebleeding due to gastric ulcer or duodenal ulcer by
intravenous injection. Administer 40 mg once a day for 4 weeks after induction of rebleeding prevention due to gastric ulcer or duodenal ulcer by intravenous injection.
2. Adolescents over 12 years of age
1) Gastroesophageal reflux disease (GERD)
- Treatment of erosive reflux esophagitis: Administer 40mg once a day for 4 weeks.
In patients whose esophagitis does not cure or the symptoms persist, take another 4 weeks.
- Symptomatic treatment of gastroesophageal reflux disease without esophagitis:
· Once a day, 20mg once a day. If symptoms are not controlled after 4 weeks, additional treatment is required.
· Once symptoms are relieved, subsequent symptoms are controlled by administering 20 mg once a day.
· For adults, 20 mg once a day can be administered as needed. For patients who are at high risk of developing gastric and duodenal ulcers due to NSAID administration, it is not recommended to administer them whenever necessary for continuous symptom control.
3. Children under
12 years of age There is no experience of administering this drug to children under 12 years of age.
4. Renal dysfunction
There is no need to adjust the dose. Since there are not many cases of administration to patients with severe renal failure, it should be administered with caution.
5. Hepatic impairment
No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the dose should not exceed 20 mg. 6. No need to adjust the
elderly dose.
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