Single-Pot Granulation – VMA
Single-Pot Granulation – VMA
Single-pot granulation has been used in the pharmaceutical industry for decades. Single-pot granulation combines the mixing, high-shear wet granulation and drying (vacuum drying, carrier-gas drying, or microwave drying) all in one process bowl.
L.B. Bohle’s single-pot granulation portfolio includes R&D systems for small production volumes as well as production-scale systems.
Single-Pot Granulation VMA 600
Granulation with the L.B. Bohle
Single-Pot Granulator
The VMA product range includes classic single-pot granulators with agitator and chopper units and a top drive. Two stirrers produce the shearing action and loosen the product. This helps to prevent clumping and ensures that the resulting granule is of optimum quality. The GMP-compliant process bowl with a double shell is the core of the VMA.
The main aggregates are integrated into the lid of the granulation pot (top drive).
The process bowl is emptied through a cone-shaped sieve (BTS 200) via the floor outlet into a container (IBC). Recipe-controlled cleaning is carried out automatically. The VMA produces batch sizes from 20 to 960 litres and can be installed in explosive atmospheres.
Benefits of the Single Pot Granulator
- Safe production inside a closed bowl in a vacuum
- High mixing and granulation efficiency (even for low doses of active agents at
- Low energy consumption: Drying at low temperatures
- Easy operation and cleaning, as well as quick product changes
- Efficient solvent recovery through cooling water
