Naphthyderyl
( NAPHTIDERILE )
Storage:
active substance: naftifin hydrochloride;
1 ml of solution contains 10 mg of naftifin hydrochloride;
excipients: propylene glycol, ethanol 96%, purified water.
Medicinal form. The solution is transdermal.
Main physico-chemical properties: transparent solution from colorless to light yellow color with the smell of ethanol.
Pharmacotherapeutic group. Antifungal agents for use in dermatology.
Code ATXD01A E22.
Pharmacological properties.
Pharmacodynamics.
Naftideril is an antifungal agent of the allylamine class, the mechanism of action of which is associated with the inhibition of the action of ergosterol.
Naftideryl is active against dermatophytes such as trichophyton, epidermophyton and microsporum, yeast ( Candida ), molds ( Aspergillus ) and other fungi (eg Sporothrix Schenckii ). With regard to dermatophytes and aspergillus, naftifin has a fungicidal effect in vitro , with regard to yeast fungi - it shows fungicidal or fungistatic activity depending on the strain of the microorganism.
Naftideryl also exhibits antibacterial activity against gram-positive and gram-negative microorganisms, which can cause secondary bacterial infections along with mycotic lesions.
In addition, Naftideril has anti-inflammatory properties and helps to quickly eliminate the symptoms of inflammation and itching.
Pharmacokinetics.
Due to the rapid penetration of the drug into the skin and the formation of stable antifungal concentrations in different layers of the skin, Naftideryl can be used once a day.
Clinical characteristics.
Indication.
Local treatment of fungal infections caused by naftifin sensitive pathogens:
- fungal infections of the skin and skin folds;
- interdigital mycoses;
- fungal nail infections (onychomycosis);
- skin candidiasis;
- bran-like lichen;
- inflammatory dermatomycoses, with or without itching;
- mycosis of the external auditory canal.
