Molecular Devices

Molecular Devices

3860 N First Street, San Jose, California, 95134

ClonePix 2 Mammalian Colony Picker

ClonePix 2 Mammalian Colony Picker

ClonePix 2 Mammalian Colony Picker

A transformative cell line development workflow with automated clone screening and optional monoclonality assurance on day 0*

A complete solution for the automated screening and objective selection of high-value clones across diverse cell types.

The ClonePix® 2 Mammalian Colony Picker is a fully automated system for selecting high-value clones used in antibody discovery and cell line development. Screen more clones in less time with monoclonal verification on day zero, then screen and identify for highest producers in weeks, not months.

Hybridomas, CHO cells, stem cells and other cell types are imaged and selected based on user-defined parameters. Plate handling, barcode reading, and picking are fully integrated, and all data, including images, are saved for downstream analysis. The picker increases the probability of finding optimally produced cell lines and significantly reduces time and labor.

Automate antibody discovery and cell line development workflows

ClonePix 2 picker is 10x faster than labor-intensive limiting dilution and FACS. Our sophisticated software and integrated robotics enable a screening speed of > 10,000 clones per day.

Select cells with desirable attributes with monoclonality assurance from day 0

Easily screen and select clones based on protein productivity, antigen-specificity, cell viability, and expression levels of tagged recombinant proteins.

Increase the probability of identifying high-value clones while eliminating or recovering unstable clones early

Picking accuracy < 1 mm. Robotic picking reduces the risk of colony disturbance. Images of picked clones are stored with data.

ClonePix 2


Multiple detection methods

White light identifies and measures clone morphology, size and proximity. Fluorescence indicates expression level and/or specificity. Up to five fluorescent filters are available for multiplexing.

Sterility maintenance

A host of sterility features and options including a UV light process for sanitizing the interior of the instrument, as well as pin washing and halogen drying are standard.

Integrated plate storage

Includes two storage stacks for source and destination plates, each with a capacity of 10 plates.

Discrete colony formation

Semi-solid CloneMediaTM encourages single cells to grow into discreet colonies, and allows for ease of plating. The media allows for a higher density of clones to be screened.

Animal-free media and reagents

Chemically defined and animal-free, CloneMedia cell-culture media, is optimized to increase productivity and aid in visualizing secreted antibodies when used with the CloneDetectTM detection agent.

Custom automation options*

The Advanced Workflow Engineering Solutions Team can customize the monoclonality system and offer added services such as integrated verification of monoclonality.

Product Enquiry

SSL Secure Connection