Ocular Therapeutix, Inc.

OTX-CSI(cyclosporine intracanalicular insert)

SUSTAINED-RELEASE PRODUCT CANDIDATE FOR DRY EYE DISEASE

OTX-CSI is a long-acting, preservative-free cyclosporine intracanalicular insert being evaluated for the treatment of dry eye disease.¹

EXISTING TREATMENTS

Slow onset of action for therapy^2,3

High level of burning and stinging upon administration^2,4

Burden of patient administration^2,4

PRODUCT CANDIDATE ATTRIBUTES⁵

Cyclosporine loaded in hydrogel

Preservative-free

Designed to deliver therapy up to 12 weeks with a single insert

Occludes the punctum

Fully biodegradable insert