Quotient Sciences

Solid State Services

Quotient Sciences has extensive expertise in solid form screening and selection with material scientists working closely with drug substance chemists to identify the most appropriate drug substance form for development. Learn more about our preformulation and material sciences capabilities.

Capabilities include:

• Salt Selection: Poor bioavailability or instability of a drug substance can often be solved/improved by screening different salt forms. The selection of the most appropriate salt can not only improve the physicochemical properties but identifying all developable salts can strengthen the intellectual property of the drug substance. The choice of counterions is typically based on the pKa of the drug substance, the relevance for the expected dosage form, and the know-how of our experts.

• Polymorph Screening: To meet regulatory requirements, the polymorphic behavior of a drug substance needs to be assessed and the polymorph chosen for development needs to be fully identified/characterized. Identifying the polymorph landscape can also strengthen intellectual property.
• Amorphous Dispersions: Amorphous forms can have increased solubility and bioavailability in comparison with their crystalline form. However crystalline materials tend to be more stable and amorphous material can recrystallize over time but can be stabilized as an amorphous solid dispersion. Whether its spray dried dispersions (SDD) or Hot Melt Extrusion (HME), our team of experts can support the enhancement needs of your molecule.
• Crystallization Development: Supporting the drug substance development team, purification steps can be improved and drug substance manufacturing yield, throughput and purity can be increased by integrating a solid state approach to recrystallization processes.