Quotient Sciences

Isotopic Labelling

Ensuring secure and rapid delivery of isotopically labeled (14C/stable isotope labeled [SIL]) materials to support your non-clinical and clinical development.

At Quotient Sciences, we are offer isotopic labelling services to support 14C human ADME studies and stable isotope labelling (SIL) for studying development candidates. Our team of experts provide guidance on the design and conduct of both non-clinical and clinical human ADME studies for research, development, and regulatory purposes. Through the use of mass spectrometry, our highly trained chemists are able to provide highly accurate measurements of test substances that aid in candidate development. Our radiochemists have extensive chemical and radiochemical knowledge and experience of isotopically labeling hundreds of molecular entities. They work closely with our analytical and drug product teams to deliver a solution-focused service to our customers throughout all stages of drug development, from candidate development to commercial.

We are experts in the safe handling of 14C-labeled high-potency/high-hazard compounds (cytotoxics) and 14C-labeled gases and volatiles, including 14CO2. Our facilities are UK Medicines and Healthcare products Regulatory Agency (MHRA)-accredited, and we offer full Good Manufacturing Practice (GMP) synthesis of 14C-labeled compounds for human studies.