It is a centrifugal processing of single unit operation.
The process involves the deposition of successive layers of an active compound onto nonpareil seeds resulting in the formation of uniform size pellets.
The operation is carried out using a Drug layering rotating plate, Dry powder dusted on nonpareils adheres, increasing their size and forming larger pellets. As per requirements.
Growth occurs by a process of process of blending of powder / liquid binding and consolidation. After liquid addition and dusting creates the correct diameter pellets, then tumbling of the coalesced aggregates increases their sphericity.
The requirements of process validation or Good Manufacturing practices (GMP) are simplified as the complete spheroid production process is restricted to a single processor, min. size possible 200 microns.
The requirements of process validation or good manufacturing practices (GMP) are simplified as the complete spheroid production process is restricted to a single processor.
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