LIPIDS & CARBOHYDRATES
CordenPharma’s scientists have mastered the chemical total synthesis of complex derivatized phospholipids from multi-gram to multi-kilogram scale and are renowned for their contract lipid and phospholipid manufacturing expertise. Our large-scale proprietary cGMP manufacturing processes start with (S)-1,2-isopropylideneglycerol ((S)-IPG) and extend over a cascade of optimised and fully-scalable conversions leading to a wide range of phospholipid molecule derivatives such as, but not limited to:
CordenPharma’s lipid manufacturers also pioneered the chemistry of hydrophilic phospholipids and large-scale manufacture of MPEG-conjugated phospholipids which can be accessed through the same synthesis cascade, rendering them superior quality products in sensitive liposome formulation processes.
In addition, standard cationic phospholipids such as DODMA and DOTAP can be made available in cGMP and R&D grade qualities.STANDARD LIPIDS
A wide selection of Readily Available Lipids Phospholipids suitable for Research & Discovery is available for purchase in convenient 1 g and 10 g pack sizes (please refer to our Lipid List for more details).
To Place An Order For Readily Available Catalog Lipids Please Contact:
BOTANICHOL® - NON-ANIMAL CHOLESTEROL
As a result of the COVID-19 pandemic in 2020, CordenPharma developed a straightforward, short synthesis of highly pure plant-derived cholesterol called BotaniChol® used in the production of lipids for mRNA vaccines.
Currently, the main quantities of cholesterol for industrial applications are extracted from wool grease of sheep or animal tissues. These sources involve the risk of Transmissible Spongiform Encephalopathies (TSEs) agents via human and veterinary medicinal products.
The new production process of BotaniChol® with non-animal origin cholesterol avoids any potential animal source of contamination, as it is based solely on chemical transformations starting with plant materials. The patented process plays an important role in overcoming the global shortage of lipids, and aiding in the production of more life-saving vaccines around the world to fight the pandemic.
In addition to our standard phosphocholine, pegylated and cationic lipids, BotaniChol® nicely completes our mRNA lipid offering for global partners involved in fighting the pandemic.
