surface-modification-technologies
PROPRIETARY SURFACE MODIFICATION TECHNOLOGY TO IMPROVE MEDICAL DEVICE SAFETY AND FUNCTIONALITY
ENDEXO® LOW MOLECULAR WEIGHT ADDITIVES FOR PASSIVE SURFACE MODIFICATION
Endexo® is a proven surface modification technology based on low molecular weight fluoro-oligomers to enhance the biocompatibility of medical devices that come in contact with blood, tissue, or other biological fluids. These additives are blended at low concentrations into a base polymer during standard manufacturing processes and migrate to the device surfaces, creating a unique surface chemistry at the interface of the device and its environment.
Being a highly versatile platform for surface modification, Endexo® can be tailored to be compatible with a broad range of base polymers (e.g. TPUs, PSU, PVC, PP, PEBA, and silicone) and manufacturing techniques (e.g. extrusion, solution spinning, and injection molding). Endexo® surface modifying additives become an integral part of the base material, providing a permanent and durable modification of surface properties with no impact on device dimensions or functionality. As a specialty chemical (not a drug or biologic), Endexo® does not require any special packaging or handling.
UP TO A 99% REDUCTION IN PLATELET ADHESION AND THROMBUS FORMATION VIA SURFACE MODIFICATION
Thrombus accumulation on blood contacting-devices such as catheters, vascular stents, or hemodialyzers can lead to adverse complications including device occlusion, deep vein thrombosis, or stroke. By reducing adhesion and activation of blood components, the Endexo® surface modification technology minimizes the risk of thrombosis and associated complications.
In-vitro blood loop studies show up to 99% reductions in thrombus on Endexo® surface modified vascular access catheters and drainage catheters, compared to unmodified devices or other commercial products.1,2,3,4 Flow studies also show Endexo® surface modified neurovascular drainage catheters were approximately eight times less likely to become obstructed than comparative commercial drainage catheters,.4,5
