L.B. Bohle Maschinen und Verfahren GmbH

Twin-Screw Granulation – BCG

Twin-ScrewGranulation – BCG

Twin-screw granulation has been the established method for continuous moist granulation since the early 2000s. Twin-screw granulation is designed as a fully continuous process and can be used by companies as a starting point for the successful introduction of continuous manufacturing of pharmaceuticals

Granulation with the L.B. BohleTwin-Screw Granulator

The BCG Twin-Screw Granulator can be used as stand-alone system or it can be fully integrated into the L.B. Bohle’s QbCon® continuous manufacture line.

The powder to be granulated is fed onto two screws, which rotate in the same direction inside a cylinder, thereby transporting the material through the process zone and kneading and mixing it at the same time. The flexible design of the screws allows producing granules of different porosities that match all requirements for downstream drying and tableting.

Twin-screw granulator with an intelligent control conceptIntelligent control concepts are used in combination with PAT (Process Analytical Technology) such as NIR (near-infrared spectroscopy) for in-line content analysis or continuous particle size analysis, or Raman spectroscopy to produce granules of consistently high quality.