Onyx Scientific Limited

Solid State Chemistry

Solid state chemistry is required to understand and control the physical properties of a drug substance.  An in-depth understanding of the API is developed through salt screening work (if applicable) where our high throughput methodology ensures a wide range of counterions and solvents are studied.  Solubility is a key parameter throughout this work and detailed solubility testing will help in making the correct choice of salt for onward study.  Understanding the range of forms an API can make and their properties is crucial to deciding on a chosen candidate. Polymorph screening provides this information by producing a detailed form diagram which summarises the findings.  Crystallization development then ensures that the chosen salt and form can be generated reproducibly.

Solid State Chemistry

Solid State Chemistry

Solid state chemistry is required to understand and control the physical properties of a drug substance.  An in-depth understanding of the API is developed through salt screening work (if applicable) where our high throughput methodology ensures a wide range of counterions and solvents are studied.  Solubility is a key parameter throughout this work and detailed solubility testing will help in making the correct choice of salt for onward study.  Understanding the range of forms an API can make and their properties is crucial to deciding on a chosen candidate. Polymorph screening provides this information by producing a detailed form diagram which summarises the findings.  Crystallization development then ensures that the chosen salt and form can be generated reproducibly.