OPKO Health, Inc

Reversible PEGylation

Our reversible PEGylation technology is a novel technique for creating extended release therapeutics. In reversible PEGylation, a conjugate is formed through a proprietary bi-functional hydrolyzable linker, between a drug that contains a primary peptide and a polyethylene glycol (PEG) chain. Once the conjugate enters the bloodstream the linker hydrolyzes at physiological pH and body temperature, releasing the intact drug in a controlled manner. Depending on the peptide or protein, the released molecule can either work locally, systemically or cross the blood brain barrier at receptor sites.