WuXi STA

Oligonucleotide Synthesis

Oligonucleotide Synthesis

Our oligo drug discovery platform has a few thousands of dedicated scientists and state-of-the-art facilities, providing oligonucleotide library synthesis (nmol - µmol) and custom synthesis (µmol – mmol) covering all oligo types including DNA, ASO, siRNA, Aptamer, PMO, etc., with or without conjugation, coupled with dedicated analytical support for all required testing.  

Oligonucleotide high throughput library synthesis (nmol - µmol)

• 192 channel synthesizers with up to 1 µmol set up for each column
• High purity by high throughput RP-HPLC or OPC™ (Oligonucleotide Purification Cartridge) purification
• Fast delivery: about 10 days to complete ~200 ds RNA

Selected past projects:

• 234 siRNA duplex library synthesis within 2 weeks (200 nmol each)
• 144 5'-SMCC DNA Aptamers library synthesis within 2 weeks (375 nmol each)
• 206 PMO library synthesis within 2 months (300 nmol each)

Oligonucleotide custom synthesis (µmol - mmol)

• Synthesizers up to 16 monomers selection enables highly modified oligo synthesis, ÄKTA OligoPilot^TM 10, ÄKTA OligoPilot^TM 100
• Expertise in long oligo synthesis for both ss RNA and ds RNA
• Experience with diverse challenging modified oligo synthesis such as ASO with all chiral phosphorothioates, RNA with 3'/5'-GalNAc, lipidation, PEGylation, etc.
• Large capacity: deliver 2,000+ oligo molecules per month, endotoxin level control (<1EU/mg)