Altasciences

Lead optimization

Lead optimization

With flexible study designs, competitive start times, and on-time reporting, we can help you determine your best candidate.

We can identify the safest molecule as part of your lead candidate selection process through a series of short-term, non-GLP screening studies to detect unusual clinical observations and pathological effects caused by the test articles being compared.

At Altasciences, each lead optimization study is unique and designed on a case-by-case basis by our scientists to meet your needs. Using abbreviated study protocols and summary reports that emphasize the use of tables over text, we aim to deliver important, decision-ready results in the shortest amount of time possible.

Single-dose, 3-5 day and 10-14 day, repeat dose studies are performed to assess the effects of test articles in rodent and non-rodent species. Designs can include multiple test articles in one study to better compare head-to-head results. Assessments usually focus on clinical observations, hematology, gross observations, and pathological evaluations of major organs.