Copley Scientific Limited,

Copley Scientific Limited,

8, Colwick Quays Business Park, Rd No 2, Colwick, Nottingham NG4 2JY, United Kingdom

BRS 100i Breathing Simulator

BRS 100i Breathing Simulator

BRS 100i Breathing Simulator

The BRS 100i is specifically designed for generating neonatal, infant, child and adult breathing patterns required for dose uniformity testing of nebulisers in accordance with ISO 27427:2013. It can also be used to generate the profiles required in USP <1602> for testing Spacers and Valve Holding Chambers used with Inhalation Aerosols.

  • Ph. Eur. 2.9.44, USP <1601>, <1602> and ISO 27427:2013 compliant
  • Intuitive, touchscreen user interface
  • Extensive data output options

BRS 100i Technical Specifications


Volume (manually adjust):

0 to 800 mL


12 - 40 bpm

I:E ratio:

1:1, 1:2 or 1:3



Patient profile suitability:

Neonate/Infant, Child, Adult


Inhalation and Exhalation


Select start on inhalation or exhalation stroke

User interface:



Testing Nebulisers (Ph. Eur. 2.9.44 and USP <1601> Testing MDIs with Spacers/VHCs (USP <1602> Improving IVIVCs for MDIs with Spacers/VHCs and nebulisers: With Filter Holder and Adapter (Dose Uniformity) With Impactor and Mixing Inlet (APSD)

Top Tip

The BRS 100i can also be used in place of a standard vacuum pump with a cascade impactor such as the NGI or ACI and a Mixing Inlet to form a simple and inexpensive system for APSD studies utilising more representative patient profiles for MDIs with and without a spacer/VHC.

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