HERMES PHARMA GmbH

HERMES PHARMA GmbH

Georg-Kalb-Strasse 582049 PullachGermany

Effervescent tablets

Effervescent tablets

Effervescent tablets

Effervescent tablets dissolve upon contact with water to release carbon dioxide and create a drink. We design and manufacture effervescent tablets that have a pleasant taste, even if they contain bitter, sulfuric, sour, metallic, astringent, or difficult-to-process APIs. All our effervescent products dissolve quickly and completely leaving no residues or foam.

The composition of our effervescent tablets helps to speed up the absorption of APIs, so they are already dissolved when entering the body. By creating a buffered solution that increases the pH value of the stomach, APIs are then quickly passed to the small intestine. Our effervescent tablets are extremely stable, meaning they are less sensitive to humidity and high temperatures and can be used in tropical regions (climatic zones III- IV).

Like all user-friendly dosage forms, effervescent tablets:

  • Are easy to take, even for those who experience difficulties swallowing conventional tablets and capsules
  • Reduce the risk of drug-induced esophagitis, which occurs when a tablet is caught in the esophagus and dissolves while remaining in contact with the sensitive esophagus lining
  • Taste pleasant and come in a range of flavors
  • Are easy and convenient to use
  • Are supplied as a single dose so no measuring is required
  • Improve compliance

Effervescent tablets:

  • Render tablet size and shape irrelevant and allow large amounts of API/nutrient (more than 2 grams) or a combination to be provided in a single dose, even at very different concentrations
  • Provide excellent bioavailability and rapid release of the API/nutrient
  • Aid rehydration by increasing liquid intake
  • Minimize the risk of gastric irritation 

In addition, effervescent tablets:

  • Can be packaged in aluminum or polypropylene tubes of different sizes and with an easy-to-open stopper, that is senior friendly as well as child resistant
  • Can also be packaged in foil strips/pouches with an aluminum-paper laminate or PET-aluminum-PE laminate to protect photosensitive APIs against light.
  • Are ideal for patients with low gastric fluid production, like those on proton pump inhibitor medications, for example

Manufacturing expertise

To deliver the benefits described above, effervescent tablets (and instant drinks) must dissolve quickly and completely upon contact with water. Furthermore, to enhance patient experience, they should dissolve without leaving unpleasant residues or foam on the surface that can impact on taste or mouthfeel.

The development of effervescent products requires specific expertise and dedicated manufacturing conditions. As they are particularly susceptible to moisture, environmental humidity must be carefully controlled at all times.

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