HERMES PHARMA GmbH

Orally disintegrating granules (ODGs)

Orally disintegrating granules (ODGs)

ODGs are fine granules or powders that are packaged into small sachets called 'stick packs'. They are poured directly into the mouth and swallowed without water, making them convenient for taking 'on the go'. By rapidly dissolving in the mouth, ODGs can provide fast onset of action, an important feature for painkillers, for example.

Like all user-friendly dosage forms, ODGs:

• Are easy to swallow, even for those who experience difficulties swallowing conventional tablets and capsules
• Reduce the risk of drug-induced esophagitis, which occurs when a tablet is caught in the esophagus and dissolves while remaining in contact with the sensitive esophagus lining
• Taste pleasant and come in a range of flavors
• Are easy and convenient to take
• Are supplied as a single dose so no measuring is required
• Improve compliance

Dosage forms that do not require water are:

• Easy to take 'on the go'
• Convenient to take, anywhere and at any time
• Ideal for those needing to reduce their daily liquid intake (e.g. dialysis patients 

In addition, ODGs offer:

• Excellent bioavailability as ODGs are dissolved/dispersed while swallowing
• The option of immediate API release (for fast-acting painkillers, for example) or slow release (extended-release formulations) - depending on the needs and indication
• Suitability for turning poorly soluble APIs into a user-friendly dosage form
• High protection of the contents: Packaged in safe and handy “stick packs” made from an aluminum-paper laminate or PET-aluminum-PE laminate that protects even photosensitive APIs against light
• Optional tear notch for easy opening
• Combinations of APIs can be formulated in one 'stick pack'