Laboratoria Smeets

Laboratoria Smeets

Fotografielaan 42
B-2610 Antwerpen,Wilrijk,Belgium.

Twin Screw Granulator

Twin Screw Granulator

New technology for API solubility

Continuous production of water soluble granules via Twin Screw Granulation

In collaboration with Ghent University, Labo Smeets has developed a technique to produce watersoluble granules; containing poorly water soluble drugs of Class II (poorly soluble, highly permeable) or Class IV (poorly soluble, poorly permeable) of the Bio Classification System (BCS).

The granulation technique – in combination with suitable excipiens as polyethyleneglycols and maltodextrins – improves the extent, but mainly the rate of dissolution of the poorly water soluble drug. The faster release of the API results often in an improved bioavailability and consequently a decreased intake of API to obtain the same clinical effect.

The technique can be applied for the production of human and veterinary medicines. Nowadays, the technique is used for the production of granules administered via drinking water to treat large groups of animals (poultry, pigs, …). The produced granules can also be filled in capsules or can be used as intermediates for the production of tablets.

The main advantages of the technique are the continuous process, the limited problems of upscaling and the absence of solvents by which no drying step is necessary.

The Twin Screw Granulator Machine for Pharma manufacturer (Pharma TSG 24) is supplied by Thermo Scientific, an important player in the production of twin screw granulators and extruders.

The equipment is operational since January 2011.

Product Enquiry

SSL Secure Connection