Jurabek Laboratories Ltd

Jurabek Laboratories Ltd

165 Almazar,Tashkent, 100003 Uzbekistan

Novocaine

Novocaine

Novocaine

  • Active ingredient (INN): Procaine
  • ATX code: N01BA02
  • Pharmacotherapeutic group:
  • Local anesthetics.

Pharmacological properties

A local anesthetic with a weak anesthetic activity and a wide range of therapeutic effects. It blocks voltage-dependent sodium channels, prevents the generation of impulses at the endings of sensitive nerves and the conduction of impulses along nerve fibers. It suppresses the conduction of impulses not only of pain, but also of another modality. First, under the influence of the drug, the feeling of cold is lost, then the sensation of heat, pain and pressure gradually disappear. With a resorptive effect, the drug has a depressing effect on the central nervous system, weakens spasms of smooth muscles, inhibits the release of acetylcholine from presynaptic endings and therefore has some ganglioblocking effect, in large doses it can disrupt neuromuscular conduction. The drug also has a hypotensive and antiarrhythmic effect (reduces excitability and automatism, impairs conduction). The duration of action with infiltration anesthesia is half an hour - an hour. The duration of action for other types of anesthesia depends on the concentration of the drug, its combination with an adrenaline solution and averages from half an hour to an hour and a half.

Indications for use

Infiltration, intraosseous anesthesia; pararenal and vagosympathetic blockade; frostbite (in the pre-reactive period); hypertension, late toxicosis of pregnancy with hypertensive syndrome, phantom pain, peptic ulcer of the stomach and duodenum, itching, neurodermatitis, eczema, keratitis, sciatica, iridocyclitis, glaucoma. It is also used to dissolve penicillin powder in order to reduce the pain of antibiotic injections.

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