Doxofylline: It is a novel xanthine broncho-dilator, which differs from Theophylline. Similarly to Theophylline, its mechanism of action is related to the inhibition of phosphodiesterase activities, but in contrast it appears to have decreased affinities towards adenosine A1 and A2 receptors, which may account for its better safety profile. The broncho-dilating activities of Doxofylline have been demonstrated in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease. In contrast to other broncho-dilators, experimental and clinical studies have shown that the drug is devoid of direct stimulatory effects. This may be of importance because the arrhythmogenic actions of broncho-dilators may have a negative impact on the survival of patients with respiratory diseases.

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